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腫瘤科醫(yī)學(xué)論文-18F2FDG PET2CT標(biāo)準(zhǔn)攝取值與NSCLC臨床病理因素的關(guān)系
［摘要］ 目的 探討非小細(xì)胞肺癌（NSCLC)病人18氟脫氧葡萄糖（18F2FDG)PET2CT標(biāo)準(zhǔn)攝取值（SUV)與臨床病理因素的關(guān)系。方法 對80例確診為NSCLC的病人治療前行18F2FDG PET2CT檢查，測得SUV最大值（SUVmax)，分析 SUVmax與原發(fā)腫瘤大小、臨床分期、病理學(xué)類型及細(xì)胞分化程度之間關(guān)系。結(jié)果 腫瘤直徑>3 cm組和≤3 cm組的SUVmax差異有統(tǒng)計學(xué)意義（t=4.17,P<0.05),不同臨床分期（Ⅰ期與Ⅲa期、Ⅲb～Ⅳ期)SUVmax差異有統(tǒng)計學(xué)意義(F=7.05，P<0.01)。SUVmax與原發(fā)腫瘤大小及臨床分期呈正相關(guān)（r=0.658，P<0.01；r=0.286,P<0.05)。結(jié)論 18F2FDG PET2CT的SUV值隨著腫瘤大小和病期的增加呈升高的趨勢，而與細(xì)胞分化程度和病理學(xué)類型無關(guān)。
【關(guān)鍵詞】 癌 非小細(xì)胞肺 18氟脫氧葡萄糖 臨床分期 標(biāo)準(zhǔn)攝取值 正電子發(fā)射斷層顯像術(shù) 體層攝影術(shù) X線計算機(jī) CORRELATION BETWEEN STANDARD UPTAKE VALUE OF 18F2FDG PET2CT AND CLINICOPATHOLOGIC FACTORS OF NON2SMALL CELL LUNG CANCER QIN CHEN, MA XUE2ZHEN (Department of Oncology, The affiliated Hospital of Qingdao University Medical College, Qingdao 266021, China);
［ABSTRACT］ Objective To investigate the correlation between standard uptake value (SUV) of 18F2FDG PET2CT and clinical factors of non2small cell lung cancer (NSCLC). Methods Eighty patients with confirmed NSCLC underwent whole2body 18F2FDG PET2CT scan before treatment. The maximal SUV (SUVmax) was obtained and its association with primary tumor size, clinical staging, pathological type, and cell differentiation of NSCLC was analyzed. Results The differences of SUVmax were significant between tumor sizes of >3 cm and ≤3 cm (t=4.17,P<0.05), and among different clinical stages (stageⅠand stages Ⅲa and Ⅲb-Ⅳ) (F=7.05,P<0.01). SUVmax showed a positive correlation with the size of primary tumor and clinical staging (r=0.658,P<0.01;r=0.286,P<0.05). Conclusion The SUV of 18F2FDG PET2CT tends to rise with the increase of tumor size and stage, but it has nothing to do with cell differentiation and the type of pathology of NSCLC.
［KEY WORDS］ Carcinoma, non2small cell lung; 18flurodeoxyglucose; Clinical staging; Standard uptake value; Positron2emission tomography; Tomography, X2ray computed
