醫(yī)學論文范文:阿加曲班對大鼠肢體缺血再灌注損傷血液流變學指標影響的實驗研究

本研究通過肢體缺血�苍俟嘧�損傷的動物實驗表明，阿加曲班可以有效改善肢體缺血�苍俟嘧⒑蟮难�液流變學異常。分析原因主要有以下2點：(1)降低血漿P�策x擇素和ICAM��1濃度，減少白細胞粘附，從而減輕全身炎性反應(yīng)。(2)直接滅活凝血酶(因子Ⅱa)的活性，避免進一步促進凝血作用的級聯(lián)反應(yīng),防止微血栓形成。綜上所述阿加曲班表現(xiàn)出對缺血�苍俟嘧�損傷的保護作用。

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