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綜上所述，我們的研究結(jié)果證實了17β_雌二醇可通過促進(jìn)iNOS蛋白表達(dá)，增加NO合成，抑制VSMCs增殖;在新生牛血清促進(jìn)VSMCs增殖過程中，caveolin_1蛋白表達(dá)降低，17β_雌二醇提前孵育可增加caveolin_1表達(dá);且17β_雌二醇可通過上調(diào)caveolin_1蛋白表達(dá)，增加iNOS表達(dá)及NO合成，抑制VSMCs增殖。此研究結(jié)果有助于進(jìn)一步明確17β_雌二醇抑制VSMCs增殖過程中caveolin_1的作用機制，加深17β_雌二醇對心血管保護(hù)作用機制的闡明。
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